I don't mean to nitpick, Tom, but is this really your plan?

See, I could have lived with "on good days you get to kill the whore of Babylon." That's a person. "A whore"? Those are women who, as coffeeandink has pointed out, are actually regularly singled out for violence, including murder--and are not responsible for the apocalypse. It's not about PC (there are ways to portray even misogyny without endorsing it; I don't believe that's what the show does), and it's not about Dean being angry and broken, which, 100% yes. It's about what the show consistently does to disempower women, which is connected to your point about reproduction. Here, that worked, in a sense--since Lisa was never a person as far as Dean was concerned, it made sense that Lisa was a stand-in for the family he wanted (and can never get with Sam). But if we're talking about the one who got away--it should've been Cassie!